McKinney's Cotton Pickers were a United States jazz band founded in Detroit, Michigan in 1926 by William McKinney, who expanded his Synco Septet to ten pieces. Cuba Austin took over for McKinney early on drums. In 1927 Don Redman left Fletcher Henderson's orchestra to become the Cotton Pickers' musical director, and he assembled a band which rivalled Henderson's and Duke Ellington's. Aiding Redman with arrangements and rehearsals with the band was the talented trumpeter-arranger John Nesbitt. Between 1927 and 1931, they were one of the most popular African-American bands.

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