Born in August 1969, Paul Santana out of Tampa, FL grew up with his family heavily into the music scene. At the age of thirteen Paul began practicing mixing on two home turntables and a Radio Shack mixer. At the age of fourteen Paul received his first job spinning at a skating rink in Tampa, FL. His love for music grew throughout high school. Paul was the DJ at all the school dances and was the resident DJ at Faces, a teen night club in Tampa.

In 1987 Paul began working for Off Limits teen night club. Paul was the DJ and the manager for 7 years with over 1000 patrons every Friday and Saturday night. Thursdays was alternative (New Wave) night, which drew 300 to 500 patrons weekly.

In 1995 the underground and rave scene grew quickly in Tampa. Paul began working at Ozone late nights. Paul had the opportunity to play along side weekly featured DJ's such as Huda Hudia, Rob-E, Icey, Baby Anne, Keoki, and many others.

In 1996 Paul joined MARZ and over the course of the next two years Paul performed at 1509, The Fantasy Ranch, Cosmos, Goldrush, Liquid City, Cream, The Edge, and 901. These residencies opened new doors for Paul, giving him the chance to perform with legendary DJ's such as Andy Hughes, Kimball Collins, Sandy, D-Extreme, J-Luv and many other of Florida's biggest named DJ's.

In 1998 Paul decided it was time to move his career to the next level. Paul sent promotional CD's and tapes to hundreds of promoters across the United States. Paul began traveling and performing in cities all over the country. This gave him the opportunity to meet and spin with world renown DJ's and artists such as Dave Seaman, B.T., Taylor, Josh Wink, Three, Monk, Jackal & Hyde, Noel Sanger, Jimmy Van M., Icey, Baby Anne, Dave London, Sharaz, Mike Nice…just to name a few. He continued to travel for the next three years while making guest appearances at venues throughout the Southeast United States.

In October 2001 Paul took residency at club Inferno in Ybor City, helping to bring the South Beach vibe to Tampa. Paul then became the resident DJ at Plush and stayed on until September 2002. During the 2003 year Paul began throwing his own parties with much success. The DJ santana birthday bash was one of the most successful parties Paul promoted with over 1500 fans attending.

In November 2003 Paul took residency at Storman's Palace Night Club in Clearwater, FL on Friday nights. Paul also is also spinning on a monthly basis (Saturday’s) at one of Tampa's best night clubs. Floyd’s at the Hard Rock Hotel & Casino from 3am till 6am. Paul also resides at Green Iguana in Tampa on Saturday nights from 10pm till 3am. In addition, Paul launched his own online dance music station entitled DJ Santana Radio. In collaboration with Club FM Radio this station features a rotating play list of DJ Santana monthly mixes un-edited. With a special mix session mix every Thursday afternoon at 4pm-ET. This has opened the doors for Paul to play with bigger artists that ever before, opening for Tiesto in November 2004, Ferry Corsten in June 2005 and on the line up for one of the countries largest electronic music events, The Ultra Music Festival in March 2005.

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